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Chiral dual-annihilator model for controllable photon upconversion and multi-dimensional optical modulation
2025 / Nature CommunicationsTriplet-triplet annihilation photon upconversion seeks efficient conversion of low-energy photons to high-energy emission. However, the triplet-triplet annihilation photon upconversion system faces limitations in emission gamut because efficient triplet-triplet energy transfer between sensitizer and annihilator relies on triplet energy matching, making it challen...
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Design of circularly polarized phosphorescence materials guided by transfer learning
2025 / Nature CommunicationsIt is highly desirable that artificial circularly polarized phosphorescent materials with high luminescence asymmetry factor (glum), narrowband emission and tunable chiral phosphorescent performance can be constructed. Especially, precise control and simultaneous independent switching of circularly polarized fluorescent and phosphorescent performance for the same...
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Albumin Corona Overturns Long-Acting Behaviors of Myristic Acid-Conjugated Quetiapine Nanosuspension
2025 / Advanced Healthcare MaterialsThis work aimed to investigate the interaction of a self-assembled myristic acid-conjugated quetiapine nanosuspension (QMN) with human serum albumin and its overturning effect on QMN’s long-acting performance. Albumin corona formation modified the physicochemical properties and pharmacokinetic profile of QMN by overturning its pH-responsiveness and nano-aggre...
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Rational Design Principles for De Novo α-Helical Peptide Barrels with Dynamic Conductive Channels
2025 / Journal of the American Chemical SocietyDespite advances in peptide and protein design, the rational design of membrane-spanning peptides that form conducting channels remains challenging due to our imperfect understanding of the sequence-to-structure relationships that drive membrane insertion, assembly, and conductance. Here, we describe the design and computational and experimental characterization of...
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Cathelicidin-BF: A Potent Antimicrobial Peptide Leveraging Charge and Phospholipid Recruitment against Multidrug-Resistant Clinical Bacterial Isolates
2025 / Journal of the American Chemical SocietyCathelicidin-BF (CatBF) is a LL-37 homologous antimicrobialpeptide(AMP) isolatedfromBungarus fasciatuswith anexceptional portfolioof antimicrobial, antiviral, antifungal, and anticancer activities. Contrary tomanyAMPs, it showeda good pharmacologicalprofilewithahalf-lifeofat least1hinserumand efficacyagainstbacterial infectionsinmice.Toevaluateitspotential against ...
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A Multifunctional Enzyme Cascade Catalytic Nanoplatform for Effective Synergistic Therapy of Rheumatoid Arthritis
2025 / Advanced Functional MaterialsInsufficient oxygen supply and elevated levels of reactive oxygen species (ROS) in rheumatoid arthritis (RA) joints synergistically exacerbate inflammation and accelerate disease progression. In this study, a hybrid nanoassembly composed of superoxide dismutase (SOD) and catalase (CAT) conjugated within a single poly(ε-caprolactone) (PCL) nanoparticle is ...
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Fabrication of a Lipopolysaccharide-Targeting Peptide-Based Colloid for Alleviating Carbapenem-Resistant Enterobacteriaceae-Induced Cutaneous Infection
2025 / Advanced Healthcare MaterialsCarbapenem-resistant Enterobacteriaceae (CRE) becomes a growing threat to human health. Many clinical isolates have shown strong resistance to commonly used antibacterial agents. Inspired by cationic amphiphiles with tandem-repeat sequence, two novel peptides termed IW (IWRRIWRRIWRRIWRR-NH2) and WI (WIRRWIRRWIRRWIRR-NH2)are designed, synthesized, and investigated i...
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A self-assembled protein β-helix as a self-contained biofunctional motif
2025 / Nature CommunicationsNature constructs matter by employing protein folding motifs, many of which have been synthetically reconstituted to exploit function. A less understood motif whose structure-function relationships remain unexploited is formed by parallel β-strands arranged in a helical repetitive pattern, termed a β-helix. Herein we reconstitute a protein β-helix ...
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Xerogel Films with Ordered Silica Nanorods Enable Fine-Tuned Polarized Structural Colors in Modular Nanocomposite Films
2025 / Advanced Materials TechnologiesThe demand for polarized structural color materials with specific optical properties drives the advancement of nanostructure-based color generation composites. Here, a facile stretched and air-dried hydrogel strategy is employed to synthesize xerogel films with uni-directionally aligned silica nanorods (SNs) for constructing polarization-dependent structural colors...
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Spin detector for panchromatic circularly polarized light detection
2025 / Nature CommunicationsCircularly polarized light (CPL) detection is crucial for optical communication, bioimaging and quantum computing. However, CPL detectors based on chiral low-dimensional perovskites face a trade-off between optoelectronic performance and CPL discrimination, and typically exhibit a CPL response within a narrow spectral range. Here, we overcome these limitations by...
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Enantioselective Se lattices for stable chiroptoelectronic processing media
2025 / Nature CommunicationsChiroptoelectronic devices are crucial for applications in quantum computing, spin optical communications, and magnetic recording. However, the limited efficiency and low stability of conventional circularly polarized light (CPL)-sensing materials have restricted their broader use. Here, we introduce atomic chiral Se nanorod (NRs) films as broadband CPL detectors...
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Predictability of environment-dependent formation of G-quadruplex DNAs in human mitochondria
2025 / Communications ChemistryMolecular crowding affects the stability of nucleic acids (DNA and RNA) and induces their non-canonical structures. As the level of molecular crowding varies spatio-temporally in cells, it would be beneficial to predict the behaviour of DNA and RNA structures depending on the local cellular environments. This has applications in human mitochondria, which possess ...
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Glycosylation of serine/threonine-rich intrinsically disordered regions of membrane-associated proteins in streptococci
2025 / Nature CommunicationsProteins harboring intrinsically disordered regions (IDRs) lacking stable secondary or tertiary structures are abundant across the three domains of life. These regions have not been systematically studied in prokaryotes. Here, our genome-wide analysis identifies extracytoplasmic serine/threonine-rich IDRs in several biologically important membrane-associated prot...
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Iron-sensing and redox properties of the hemerythrin-like domains of Arabidopsis BRUTUS and BRUTUS-LIKE2 proteins
2025 / Nature CommunicationsIron uptake in plants is negatively regulated by highly conserved hemerythrin (Hr) E3 ubiquitin ligases exemplified by Arabidopsis thaliana BRUTUS (BTS). Physiological studies suggest these are the elusive plant iron sensors, but biochemical evidence is lacking. Here we demonstrate that the N-terminal domains of BTS and BTS-LIKE2 (BTSL2) respectively bind three a...
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Stability convergence in natural antibodies with ultra-long hypervariable loops
2025 / Communications BiologyAntibodies bind to antigens with hypervariable loops called complementarity-determining regions (CDRs). In contrast to conventional antibodies, a subset of bovine antibodies has an ultra-long CDR (ulCDR) composed of up to 70 residues folded as a stalk and knob. The fundamental principles of how these antibodies maintain their structure and stability remain enigma...
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