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Flexible superblack materials are crucial for minimizing stray light, complicating object identification, and serving as low reflectance standards. However, the applications of existing superblack materials are limited due to challenges related to cost-effective scalable manufacturing, surface durability, and material conformability. Furthermore, existing fabrica...
Continue readingThis work aimed to investigate the interaction of a self-assembled myristic acid-conjugated quetiapine nanosuspension (QMN) with human serum albumin and its overturning effect on QMN’s long-acting performance. Albumin corona formation modified the physicochemical properties and pharmacokinetic profile of QMN by overturning its pH-responsiveness and nano-aggre...
Continue readingSemiconducting polymers are of interest due to their solution processibility and broad electronic applications. Electrochemistry allows these wide bandgap semiconductors to be converted to conducting polymers by doping such polymers at various potentials. When polymers are p-doped to improve their conductivity via electrochemical oxidation, various positively-charg...
Continue readingMolybdenum disulfide (MoS2) is a high theoretical capacity (670 mAh g−1) electrode material. However, several researchers report that rechargeable batteries using MoS2 often exhibit a discharge capacity of 1000 mAh g−1 that exceeds the theoretical discharge capacity. Although various speculations are proposed, only a limited number of reports have provi...
Continue readingDespite advances in peptide and protein design, the rational design of membrane-spanning peptides that form conducting channels remains challenging due to our imperfect understanding of the sequence-to-structure relationships that drive membrane insertion, assembly, and conductance. Here, we describe the design and computational and experimental characterization of...
Continue readingDeveloping full-color circularly polarized organic ultralong room-temperature phosphorescence (CP-OURTP) materials with high dissymmetry factor (glum) holds significant promise for diverse optoelectronic applications. Controlling glum values is crucial for enhancing the performance and functionality of these materials, as it directly influences their chiroptical ...
Continue readingThe design and development of solar-blind photodetectors utilizing ultrawide bandgap semiconductors have garnered significant attention due to their extensive utility in specialty commercial sectors. Solar-blind photodetectors that display excellent photosensitivity, fast response time and are produced using cost-effective fabrication steps will fulfill the perfo...
Continue readingCathelicidin-BF (CatBF) is a LL-37 homologous antimicrobialpeptide(AMP) isolatedfromBungarus fasciatuswith anexceptional portfolioof antimicrobial, antiviral, antifungal, and anticancer activities. Contrary tomanyAMPs, it showeda good pharmacologicalprofilewithahalf-lifeofat least1hinserumand efficacyagainstbacterial infectionsinmice.Toevaluateitspotential against ...
Continue readingInsufficient oxygen supply and elevated levels of reactive oxygen species (ROS) in rheumatoid arthritis (RA) joints synergistically exacerbate inflammation and accelerate disease progression. In this study, a hybrid nanoassembly composed of superoxide dismutase (SOD) and catalase (CAT) conjugated within a single poly(ε-caprolactone) (PCL) nanoparticle is ...
Continue readingBrine is an inevitable product of desalination plants and various industrial sectors. The appropriate disposal of brines and their highly concentrated salts and other diverse contaminants is a critical environmental challenge to most plants. Recently, the FO process is gaining attention as a viable alternative to conventional brine concentration methods, primaril...
Continue readingCarbapenem-resistant Enterobacteriaceae (CRE) becomes a growing threat to human health. Many clinical isolates have shown strong resistance to commonly used antibacterial agents. Inspired by cationic amphiphiles with tandem-repeat sequence, two novel peptides termed IW (IWRRIWRRIWRRIWRR-NH2) and WI (WIRRWIRRWIRRWIRR-NH2)are designed, synthesized, and investigated i...
Continue readingCarbon fibre (CF) is a lightweight next-generation material with numerous applications. CF production is predominantly based on the polyacrylonitrile (PAN) precursor because of the high tensile strength of PAN-based CFs (PAN-CFs). However, expensive and toxic organic solvents are required for PAN-CF production. Moreover, the corresponding thermal stabilisation pr...
Continue readingEnergy-Coupling Factor (ECF) transporters are ATP-binding cassette (ABC) transporters essential for uptake of vitamins and cofactors in prokaryotes. They have been linked to pathogen virulence and are potential targets for antimicrobials. ECF transporters have been proposed to use a unique transport mechanism where a substrate-translocating subunit (S-component) ...
Continue readingAt present, one of the main priorities for analysts is creating more sustainable and environmentally friendly methods for pharmaceutical analysis. In this context, three innovative spectrophotometric techniques, using tri-colored (green, blue, and white), were optimized and developed to simultaneously assess two antihypertensive drugs, Nebivolol hydrochloride (NE...
Continue readingThe use of biogenic nanoparticles as targeted drug delivery systems has gained increasing attention for improving anticancer therapies. This study investigates the effectiveness of porous biosilica derived from the diatom Chaetoceros sp., functionalized with hydrophilic GPTMS, labeled with CD-19 antibody, and loaded with doxorubicin in targeting Raji cells, a B l...
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